1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It is widely used for assessing kidney function and staging chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( SCr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — Black race multiplier

Explanation: The equation uses serum creatinine levels adjusted for age, gender, and race to estimate kidney filtration rate.

3. Importance of GFR Calculation

Details: GFR estimation is essential for detecting kidney dysfunction, monitoring disease progression, and guiding treatment decisions in patients with renal impairment.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate in patients with established kidney disease, while CKD-EPI performs better at higher GFR levels and is less likely to over-diagnose CKD.

Q2: What are the limitations of the MDRD equation?
A: Less accurate in elderly patients, those with normal or near-normal kidney function, and populations with extreme body composition.

Q3: When is MDRD equation preferred?
A: Often used for staging chronic kidney disease and in patients with known renal impairment for monitoring disease progression.

Q4: How often should GFR be monitored?
A: Frequency depends on clinical context - from every 3-12 months in stable CKD to more frequently during acute illness or medication changes.

Q5: Can this calculator be used for children?
A: No, the MDRD equation is validated for adults only. Pediatric patients require age-specific equations.