Calculating eGFR From Creatinine

CKD-EPI Equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What Is Calculating eGFR From Creatinine?

Calculating eGFR from creatinine involves using the CKD-EPI equation to estimate glomerular filtration rate based on serum creatinine levels, age, gender, and race factors.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \]

Where:

\( eGFR \) — Estimated Glomerular Filtration Rate (mL/min/1.73 m²)
\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( age \) — Age in years

Explanation: The equation calculates kidney function by accounting for the non-linear relationship between serum creatinine and glomerular filtration rate.

3. Importance Of eGFR Calculation

Details: eGFR calculation is essential for assessing kidney function, diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate medication dosages.

4. Using The Calculator

Tips: Enter serum creatinine value in mg/dL, age in years, select gender and race. Ensure all values are within valid ranges (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What Is eGFR?
A: eGFR stands for estimated Glomerular Filtration Rate, which measures how well your kidneys are filtering waste from your blood.

Q2: Why Use Serum Creatinine For eGFR Calculation?
A: Serum creatinine is a waste product from muscle metabolism that kidneys filter out, making it a reliable marker for kidney function assessment.

Q3: What Are Normal eGFR Values?
A: Normal eGFR is generally 90 mL/min/1.73m² or higher. Values below 60 for three months or more may indicate chronic kidney disease.

Q4: How Often Should eGFR Be Calculated?
A: Frequency depends on individual risk factors, but typically annually for at-risk populations or as recommended by healthcare providers.

Q5: Are There Limitations To This Calculation?
A: The calculation may be less accurate in elderly individuals, those with extreme muscle mass, amputees, pregnant women, or people with rapidly changing kidney function.